ABSTRACT
According to one pot microwave assisted synthesis, the versatile precursor 2- aminothiazole was prepared and utilized for the construction of new thiazole hybrids targeting MCF7 cell lines. 2‐amino thiazole was condensed with corresponding aldehydes to yield Schiff’sbase (2) intermediates followed by the diazo coupling reaction furnished the designed hybrids(3) contains azo-methine and diazo linkages in its structures. The newly synthesizedcompounds were confirmed on the basis of IR and H1NMR spectral analytical data. All thesynthesized compounds were evaluated for their in-vitro cytotoxicity activity against MCF-7celllines using MTT assay method. The obtained results revealed the more promising compoundsof the synthesised series, 3B and 3H with CTC50 value of 17.77±0.31μg/ml, 17.83±1.14 μg/ml.
ABSTRACT
Background: However, lindernia species were considered as weeds, they occupy amost important place in the traditional system of medicine used worldwide especially in China.Linderniaceae is a family having high traditional medical summary with less pharmacognostical,phytochemical and biological profile. Objective: This study was designed to identify andcharacterize the phytochemical profile of different crude extracts of newly identified wholeplant Lindernia madayiparense, using gas chromatography–mass spectrometry (GC- MS).Method: Powdered plant material was extracted and evaluated for various in-vitropharmacological activities. Furthermore the potent extracts were analyzed by GC- MS. Results:The obtained Total ion chromatogram of potent extracts revealed the different types of havingsmall and moderate phytochemicals under the classification of alkaloids, glycosides, terpenoidsand phenols in major and minor amount. Conclusions: The study gives a detailed insight aboutthe phytochemical profiles of three crude extracts of Lindernia madayiparense. So thechemical entities found are may be responsible for the pharmacological activities that probablywill act as lead molecules for furthermore drug development process.